David D. Markwardt
Assistant Professor

Office: Rm. 302 CWSC
Phone: (740) 368-3880

Biography

Courses taught

Research interests

Curriculum Vitae

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Biography:
Professor Markwardt did both his undergraduate and graduate work at the University of Wisconsin-Madison. As an undergraduate he majored in Zoology. In grad school he received his PhD in Pharmacology, with a research emphasis on Cell and Molecular Biology. Dr. MarkwardtI did a three-year postdoctoral fellowship in Genetics, funded by the National Institutes of Health, also in Madison. He likes to spend his free time reading or hiking with his wife, Rachel. He also follows the Green Bay Packers with joy, and the Milwaukee Brewers with never ending angst.

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Courses taught:

Click on a course title to view a brief description of that course.

Dr. Markwardt currently teaches Introduction to Cell Biology, Cell and Molecular Biology Zoology, and
Immunology.

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Research interests:

Professor Markwardt is interested in the biology of messenger RNA. Specifically, his lab focuses on the mechanisms cells use to regulate mRNA degradation in order to modulate gene expression. He uses the soil nematode C. elegans and the budding yeast S. cerevisiae as model organisms.

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David D. Markwardt

Assistant Professor of Zoology
Department of Zoology
Ohio Wesleyan University Delaware, OH 43015
(740) 368-3880
ddmarkwa@owu.edu

Education:
B.S. Zoology, University of Wisconsin-Madison (1991)
Ph.D. Pharmaceutical Sciences (Pharmacology), University of Wisconsin-Madison (2000)

Research Experience:

2000-2003 Postdoctoral Fellow, Department of Genetics, University of Wisconsin-Madison (with Dr. Philip Anderson). Global studies of eukaryotic mRNA decay pathways using high density DNA microarrays.

2000 Doctoral Dissertation, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison (with Dr. Warren Heideman). Coordination of growth and division in Saccharomyces cerevisiae by the G1 cyclin, CLN3.

1992-2000 Graduate Research Assistant, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison (with Dr. Warren Heideman). Studies of signal transduction mechanisms involved in the nutrient regulation of cell division in the budding yeast Saccharomyces cerevisiae.

Publications:

Laabs, T. L.*, Markwardt, D. D.*, Slattery, M. G., Newcomb, L. L., Stillman, D. J., and Heideman, W. (2003) ACE2 is required for daughter cell-specific G1 delay in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. 100:10275-10280.
*T.L.L. and D.D.M. contributed equally to this work

Hall, D. D., Markwardt, D. D., Parviz, F., and Heideman, W. (1998) Regulation of the Cln3-Cdc28 kinase by cAMP in Saccharomyces cerevisiae. EMBO J., 17(15); 4370-4378.

Parviz, F., Hall, D. D., Markwardt, D. D., and Heideman, W. (1998) Transcriptional regulation of CLN3 expression by glucose in Saccharomyces cerevisiae. J. Bacteriol., 180(17); 4508-4515.

Markwardt, D. D., Garrett, J. M.., Eberhardy, S., and Heideman, W. (1995) Activation of the Ras/cyclic AMP pathway in the yeast Saccharomyces cerevisiae. J. Bacteriol., 177(23); 6761-6765.

Russell, M., Bradshaw-Rouse, J., Markwardt, D. D., and Heideman, W. (1993) Changes in gene expression in the Ras/adenylate cyclase system of Saccharomyces cerevisiae: correlation with cAMP levels and growth arrest. Mol. Biol. Cell, 4; 757-765.

In preparation:
Mitrovich, Q. M., Markwardt, D. D., and Anderson, P. (2002) Psuedogene surveillance in Caenhorhabditis elegans.

Markwardt, D. D., Mitrovich, Q. M., and Anderson, P. (2002) The role of mRNA surveillance in the autoregulation of alternative splicing of the C. elegans SR gene family.

Abstracts/Posters:

2002 RNA 2002. Seventh Annual Meeting of the RNA Society, Madison, WI USA. "Natural targets of nonsense mediated mRNA decay identified using C. elegans microarrays".

2001 13th Biennial International Caenhorhabditis elegans Conference, Los Angeles, CA USA. "A screen for natural targets of NMD using C. elegans whole genome microarrays ".

2000 Yeast Genetics and Molecular Biology 2000, Seattle, WA USA. "Loss of upstream CLN3 and BCK2 regulatory sequences produces cells that cannot regulate G1".

1996 Yeast Genetics and Molecular Biology 1996, Madison, WI USA. "Development of a yeast assay system to study activation properties of the zebrafish (Danio rerio) aryl hydrocarbon (Ah) receptor".

Funded Grants and Fellowships:

2001-2003 Individual National Research Service Award (NRSA): National Institute of General Medical Sciences, NIH. "A genome-wide screen for targets of mRNA surveillance".

Teaching Experience:

1999-2002 Lecturer, Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison

1998 Instructor, Department of Life Sciences, Edgewood College, Madison, WI.

1998 Teaching Assistant, Department of Zoology, University of Wisconsin-Madison.

1992-1999 Teaching Assistant in the Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin-Madison.

Awards:

2001 Rennebohm Dissertator Award - Outstanding Dissertation in Pharmaceutical Sciences, University of Wisconsin-Madison.

1999 UW-Madison, Vilas Travel Award

1998 Zaman-Saroya Outstanding Graduate Student, School of Pharmacy, University of Wisconsin-Madison.

1993 Rennebohm Teaching Award - Outstanding Teaching Assistant in Pharmaceutical Sciences, University of Wisconsin-Madison.

Graduate Courses: Ph.D. University of Wisconsin-Madison

1994 Toxicology I/II
Seminar in Cell Biology
Flow Cytometry and cell Sorting
Fungal and Yeast Genetics

1993 Seminar in Cell Biology
Comprehensive Human Biochemistry
Laboratory Techniques in Pharmacology
Eukaryotic Cell and Molecular Biology
Pharmacology II

1992 Pharmacology I
Cellular Biology
Prokaryotic Molecular Genetics

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